IMPACT OF OMEGA -3 ON HEALING OF BUCCAL TRAUMATIC ULCER OF ALBINO RATS (HISTOLOGICAL AND IMMUNOHISTOLOGICAL STUDY)

Nesreen Abdelsalam, Sally Aboubakr
2017 Egyptian dental journal  
Ulcers are one of the most frequent diseases affecting the oral cavity. The aim of this study was to assess the impact of omega-3 on healing of buccal traumatic ulcer in rat. Materials and methods: In this study adult male rats in 2 groups (n = 15 per group) were used. A wound circular in shape (4 mm diameter and 2 mm depth) was punched into the buccal mucosa of each rat using biopsy punch. The control group was not treated, the study group was treated with 93mg/kg body weight omega-3 that was
more » ... t omega-3 that was guided to the stomach by gastric gavage. Histological samples were harvested on post-injury days 3, 7 and 14. Results: The study group had high reepithelialization and connective tissue healing score on day 7 and 14. The control group had high inflammation score on day 3 and 7, and low reepithelializtion score on day 3, 7 and 14. Conclusion: Omega-3 compound increases fibroblast counts and decreases inflammatory cell counts, and also causes an increase in reepithelialization and epithelial thickness. (3194)
doi:10.21608/edj.2017.76171 fatcat:7ss7kfqmkvf4xebe47d664ubdq