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PWE-087 Colonoscopy demand and adherance to polyp surveillance guidelines
2012
Gut
Preserved Fulltext
Methylation of the SFRP4 promoter was significantly (p¼0.001) greater in biopsies from those at higher CRC risk. In addition, increasing age (a strong modulator of CRC risk) was significantly (p<0.001) associated with increased SFRP4 methylation. Conclusion This study showed that SFRP4 methylation is significantly greater in macroscopically normal rectal biopsies from those at higher CRC risk. This aberrant epigenetic mark may be causal for CRC risk and further studies are needed to investigate
doi:10.1136/gutjnl-2012-302514d.87
fatcat:viimw2gyhbebrlabqztmzf67ci