Proteomic and Bioinformatics Tools to Understand Virulence Mechanisms in Staphylococcus aureus

Malik Altaf Hussain, Flavia Huygens
2012 Current Protoemics  
Staphylococcus aureus, one of the major pathogenic bacteria, is associated with substantial morbidity and mortality. The disease burden of staphylococcal infections is significant, which is primarily attributed to its adaptability and resistance to environmental stresses. S. aureus has the ability to develop multiple resistances to antimicrobial agents. These high resistances make pathogenicity of S. aureus one of the most complex mechanisms to understand and manage. Proteomic approaches show
more » ... eat potential in exploring microbial adaptation strategies, ability to cause disease by pathogenic bacteria and the development of diagnostic tools. A summary of the latest developments in the application of proteomic technologies to understand resistance mechanisms in S. aureus and their future role in antistaphylococcal vaccine and/or drug discovery is given here.
doi:10.2174/157016412799746245 fatcat:dqwtqassl5a7xb6evkn37de4ga