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Biglycan, a Nitric Oxide-regulated Gene, Affects Adhesion, Growth, and Survival of Mesangial Cells
2003
Journal of Biological Chemistry
During glomerular inflammation mesangial cells are the major source and target of nitric oxide that profoundly influences proliferation, adhesion, and death of mesangial cells. The effect of nitric oxide on the mRNA expression pattern of cultured rat mesangial cells was therefore investigated by RNA-arbitrarily-primed polymerase chain reaction. Employing this approach, biglycan expression turned out to be down-regulated timeand dose-dependently either by interleukin-1-stimulated endogenous
doi:10.1074/jbc.m210574200
pmid:12719420
fatcat:e3qjcnlayrcmtchmuvbvvdxyiu