Wolfram Karenovics, M. Licker, M. Christodoulou, J. Diaper, C. Bhatia, P. Bridevaux, F. Triponez
<span title="2016-08-26">2016</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/c5zssmg5c5bt3cd6d4q7kvf65m" style="color: black;">Interactive Cardiovascular and Thoracic Surgery</a> </i> &nbsp;
Objectives: Exercise-based rehabilitation programs have been shown to improve both aerobic fitness and quality of life among cancer patients. So far, the long-term functional impact of preoperative exercise intervention has not been examined in patients awaiting lung cancer surgery. The aim of this study was to evaluate the effectiveness of a high-intensity training (HIT) program on postoperative functional outcome. Methods: Randomized controlled trial, two centres patients scheduled to undergo
more &raquo; ... lung cancer resection were randomized into usual care or rehabilitation arm (UC and Rehab groups). Preoperative rehabilitation was conducted by physiotherapists and consisted in 2 to 3 HIT sessions per week. Postoperative clinical outcome data included postoperative mortality, lung volume, lung diffusion capacity and aerobic fitness parameters ( peak oxygen uptake [VO 2peak] , and maximal work [W max ]). To analyze the impact of treatment and time, Student t-test, Mann-Whitney or Wilcoxon U-tests, the Pearson χ 2 test and ANOVA were used. Results: Over a 3-year period, a total of 189 patients were screened, and 151 were analyzed (N = 77 in UC group and N = 74 in Rehab group). Groups were comparable. The median time delay from enrollment to surgery was 26 days (interquartile 25-75%, 21-33 days). The HIT program prevented the impairment in aerobic fitness parameters in rehabilitated patients before surgery as reflected by significant increases in VO 2peak (median +15% [IQ 25-75, +9 to +22%]) and in maximal power (median +6% [IQ 25-75, 0 to +17%]). At one year following lung cancer surgery, there was no significant difference between the two groups regarding mortality rate (9.1% in UC group vs 6.8% in Rehab group), lung pulmonary function tests and aerobic fitness parameters. Conclusion: This study indicates that preparing patients with a HIT program enhanced aerobic fitness parameters before surgery but failed to improve survival and functional parameters one year following lung cancer surgery. Disclosure: No significant relationships. Interactive CardioVascular and Thoracic Surgery
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