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Malaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responsesdoi:10.1590/s0100-879x1998000300002 pmid:9698780 fatcat:onuspqblljfuzfb3k5bbarrbbi