INVESTIGATIONS OF FIBRINOGEN/FIBRIN DEGRADATION PRODUCTS (FDP) IN ALLERGIC DISEASES

R Alahverdyan, K Denchev
unpublished
Communications about fibrinolysis activation in allergic diseases go back a long way. Reactions antigen-antibody induce an intravascular coagulation followed by fibrinolysis in clinical and experimental conditions (1, 11). There is even a parallelism between the degree of this proteolysis and the severity of the allergic reactions. One observes plasminogen/plasmin system activation accompanied by consumption of coagulation factors and FDP entrance into the circulation in an experimental model
more » ... xperimental model of anaphylactic shock (6, 7). On the basis of these results certain authors use inhibitors of fibrinolysis in the treatment of allergic diseases (3). There are reports about changes of the fibrinolytic blood activity in such conditions. However, observations on FDP level are rather scanty in these diseases. That is why we decided to study the values of these products together with the level of soluble fibrin monomeric complexes (FMC) and of the fibrinolytic activity of the blood in various allergic diseases. Material and methods Our investigation covered 38 patients with allergic diseases. Patients with drug-induced allergy and different skin manifestations such as: allergic derma-titis, erythema exudativum multiforme, urticaria, Quincke's oedema, serum disease, allergic shock, predominated within the contingent examined. Broad-spectrum antibiotics prevailed amids drugs. There were a few cases of allergy Caused by analgin, bromates, and iodine contrast media. Investigations of patients were performed at the onset immediately after hospitalization before administration of corticosteroid therapy. FDP were quantitatively determined in the serum by using of Merskey's et al. (1966) immunological method, FMC-after Lipinski et al. (1968) and fib-rinolytic activity (FA) by means of euglobulinolysis (2). Results and discussion Our data obtained were demonstrated on table 1. It could be seen that mean FDP and FMC levels increased statistically significantly while FA did not change. These indices were examined once more in all the patients after disappearing of the allergic manifestations. The time lag between primary and secondary examinations varied in accordance with the nature of the disease. These indices returned to normal. The rest coagulogram parameters were within normal ranges although some of them showed statistically reliable differences in comparison with these of healthy persons. We observed an excessive increase of FDP up to 640 mg/1, of FMC up to 1.4 OU, of fibrinogen up to 1.43 g/1, and thrombocytes up to 190.10^/1 in one case
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