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An optimized workflow to generate and characterize iPSC-derived motor neuron (MN) spheroids
Motor neuron diseases (MNDs) are characterized by the progressive degeneration of motor neurons (MNs) from the cortex, brainstem and/or the spinal cord. In an effort to understand the underlying causes of this selective degeneration, a multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived MNs have been developed. Moreover, different groups have started to use advanced 3D structures, composed of MNs and other cell types to increase the physiological relevance of suchdoi:10.1101/2022.09.22.509079 fatcat:4uqmausmhbggxmdukgoa7ncdkm