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Influence of radiation exposure pattern on the bone injury and osteoclastogenesis in a rat model
2019
International Journal of Molecular Medicine
Radiotherapy, one of the clinical treatments of cancer, is accompanied by a high risk of damage to healthy tissues, such as bone loss and increased risk of fractures. The aim of the present study was to establish a rat model of local and systemic bone injury by focal irradiation, in order to study the etiological mechanism and intervention. The proximal metaphyseal region of the left hindlimb of male Sprague‑Dawley rats were exposed to a single 2 Gy or three 8 Gy doses delivered on days 1, 3
doi:10.3892/ijmm.2019.4369
pmid:31638191
pmcid:PMC6844641
fatcat:5yidpu3vqnc2jc3lsqtbnlaydi