Identification of a new bovine viral diarrhea virus subtype in the Republic of Korea

Du-Gyeong Han, Ji-Hyung Ryu, Jinho Park, Kyoung-Seong Choi
<span title="2018-08-07">2018</span> <i title="Springer Nature America, Inc"> <a target="_blank" rel="noopener" href="" style="color: black;">BMC Veterinary Research</a> </i> &nbsp;
Bovine viral diarrhea virus (BVDV) is prevalent in Korean indigenous cattle, leading to substantial economic losses. This study was conducted to investigate the occurrence of BVDV. In 2016, a total of 143 blood samples were collected from asymptomatic Korean indigenous calves younger than 3-months of age from six different farms in the Republic of Korea (ROK). Results: Eighty-seven calves (60.8%, 87/143) were tested positive for BVDV as evaluated by RT-PCR analysis. Phylogenetic analysis based
more &raquo; ... n the 5′-untranslated region was used to classify these cases into three subtypes: BVDV-1b, BVDV-1o, and BVDV-2a. These results showed that BVDV-1b was the predominant subtype, while 2 samples clustered with BVDV-2a. Interestingly, one sample formed a separate group as a potentially new subtype, BVDV-1o. To our knowledge, this is the first report of BVDV-1o infection in Korean native calves. The BVDV-1o subtype identified in this study was closely related to cattle isolates obtained from Japan, indicating that this subtype is a new introduction to the ROK. Conclusions: This study provides useful information for carrying out epidemiological surveys of BVDV in the ROK and developing a vaccine for future use in the ROK, particularly for the first detection of BVDV-1o in Korean indigenous calves. Further studies are required to investigate the prevalence and pathogenicity of this BVDV-1o subtype.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1186/s12917-018-1555-4</a> <a target="_blank" rel="external noopener" href="">pmid:30086756</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC6081834</a> <a target="_blank" rel="external noopener" href="">fatcat:nvvwjqet5jhe7gxc7auqahqycy</a> </span>
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