Cerebral function in diabetes mellitus

B. Bravenboer, D. W. Erkelens, W. H. Gispen, G. J. Biessels, A. C. Kappelle
1994 Diabetologia  
Diabetes mellitus is a common metabolic disorder associated with chronic complications such as nephropathy, angiopathy, retinopathy and peripheral neuropathy. Diabetes is not often considered to have deleterious effects on the brain. However, long-term diabetes results in a variety of subtle cerebral disorders, which occur more frequently than is commonly believed. Diabetic cerebral disorders have been demonstrated at a neurochemical, electrophysiological, structural and cognitive level;
more » ... , the pathogenesis is still not clear. Probably alterations in cerebral blood supply and metabolic de-rangements play a role, as they do in the pathogenesis of diabetic neuropathy. Furthermore, the brain is also affected by recurrent episodes of hypoglycaemia and poor metabolic control. We describe herein the cerebral manifestations of diabetes and discuss the putative pathogenetic mechanisms. [Diabetologia (1994) 37: 643-650] Diabetes mellitus is one of the most common serious metabolic disorders in man. Clinically, it is not one but rather a group of related diseases characterised by chronic hyperglycaemia. Diabetes care and research focus on adequate glycaemic control and on the prevention and treatment of diabetic complications. These complications result from a complex interplay between direct and indirect metabolic consequences of insulin deficiency and additional genetic and environmental factors [1] [2] . Major long-term complications are nephropathy, retinopathy, angiopathy and neuropathy. Diabetic neuropathy can involve almost any peripheral nerve and is a major cause of morbidity among diabetic patients [3--5]. Compared to complications in the peripheral nervous system, the diabetic complications in the central
doi:10.1007/s001250050159 pmid:7958534 fatcat:b2s6ajnurbbdvohepvkpeu2pze