Activation of Extracellular Signal-regulated Kinase by Ultraviolet Is Mediated through Src-dependent Epidermal Growth Factor Receptor Phosphorylation

Daiju Kitagawa, Shuhei Tanemura, Shinya Ohata, Nao Shimizu, Jungwon Seo, Gen Nishitai, Tomomi Watanabe, Kentaro Nakagawa, Hiroyuki Kishimoto, Teiji Wada, Tohru Tezuka, Tadashi Yamamoto (+2 others)
2001 Journal of Biological Chemistry  
Ultraviolet (UV) irradiation stimulates stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/ JNK), which is a member of the mitogen-activated protein kinase (MAPK) superfamily and implicated in stress-induced apoptosis. UV also induces the activation of another MAPK member, extracellular signal-regulated kinase (ERK), which is typically involved in a growth-signaling cascade. However, the UV-induced signaling pathway leading to ERK activation, together with the physiological role, has
more » ... remained unknown. Here we examined the molecular mechanism and physiological function of UV-induced ERK activation in human epidermoid carcinoma A431 cells that retain a high number of epidermal growth factor (EGF) receptors.
doi:10.1074/jbc.m107110200 pmid:11694531 fatcat:scw2kqgtkbfmtpepipxvkz7w64