Total joint arthroplasty is the primary intervention in the treatment of end-stage osteoarthritis. The majority of joint arthroplasties will last the whole lifetime. However, in some patients, the replacement will fail during their lifetime requiring a revision of the implant. These revisions are strenuous for the patient and costly for health care. To avoid a revision, therefore, is the uttermost goal of modern orthopedics. Joint replacement at a younger age, in combination with a more active

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... ifestyle, increases the need for an early revision of the joint prosthesis. The main reason for revision surgeries is aseptic loosening, a condition where the prosthesis is loosening due to bone degradation at the peri-prosthetic interface in the absence of infections. The most well-established pathological mechanism for aseptic loosening is related to wear particles, generated from different parts of the prosthesis that will trigger bone degradation and bone loss. Many people have supported me during my time as a Ph.D. student and I am deeply grateful. I want to highlight a few people specifically, as they contributed significantly to my success: Anna Fahlgren Thank you for giving me the opportunity to become part of your research team and guiding me to become a creative, but also a critical researcher. I am grateful for the freedom you gave me throughout my education to develop my personal and professional skills. Per Aspenberg Thank you for your help and support at the beginning of my education. Sadly, you were not able to see my full ended metamorphosis to a critical researcher. You will always be remembered. Mikael Sigvardsson Thank you for stepping in as my co-supervisor and your support with human stem cell biology. Aneta Liszka Thank you for being there and helping me; for all the endless hours in the cell culture labor with fluid flow experiments; for your (emotional) support when things went rough or got stressful; for always having a contagious happy attitude which just kept us going. Pernilla Eliasson Thank you for always having an open door and taking your time for discussions. Malin Hammerman, Magnus Bernhardsson, Love Tätting, and Olof Sandberg Thank you for all the help, fun discussions about research and the world outside research in the lunchroom. Franciele Dietrich Zagonel Thank you for all your help and emotional support during my Ph.D.. You always had an open ear to hear out my concerns and help me to lift my problems. I also loved, that you tried to recreate some of my recipes. Astrid Bakker, Cor Semeins, and Jenneke Klein-Nulend Thank you for taking me into your Laboratory at Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam (ACTA) and teaching me the ways of fluid flow simulation. All people, working at the animal facility, core facility, former KEF, cell biology floor 9 and 10. Thank you for all the help during my education, discussions we had in the lunchroom, and after-work events. xiii I want to thank my friends, for being at my side during these years to support me and help me to enjoy the small things in life outside research. Anna-Maria Andersson Your encouragements and support during long shopping days or strolls through nature always helped me to keep my aim in focus and not be discouraged by small drawbacks. Thank you for all the baking events and countless cakes we went through while discussing our Ph.D. experiences. Sofia Eleftheriadis Thank you for always showing interest in my research and listing to endless stories about the life of a Ph.D. student. I really enjoyed our weekly sessions in the swimming pool where we could just talk about everything -I miss those times after you left Linköping. Thank you too, for all the baking events and countless cakes we ate. Héctor Rodríguez Déniz Thank you for being such a great housemate during our stay in Lysingsgatan. It was always great fun during the movie nights and endless discussions about everything and anythingwith or without cake. During my Ph.D., I had the opportunity to support students during their final project. you all for letting me support you during your final projects. It was a pleasure to see you grow into a more independent and critical researcher over time, which also helped me to develop even further as a researcher. Einen ganz besonderen Dank möchte ich meiner Familie aussprechen. Ohne sie wäre es mir noch möglich gewesen meine Träume zu verwirklichen. Ich danke euch und hab euch lieb, von ganzem Herzen. Meiner Mutter, Christine Bratengeier: Danke Mama, für all deine Unterstützungen und Aufmunterungen! Ohne deine Unterstützung hätte ich es niemals so weit gebracht. Du hattest immer ein offenes Ohr, wenn die Situationen schwierig wurden und hast mich immer daran erinnert, wie stolz du auf mich bist. Meiner Großmutter, Leopoldine Ulbricht: Danke Omili, für all deine Unterstützungen! Auch wenn uns die Distanz schwergefallen ist, war es jedes Mal ein großartiges Gefühl nach Hause zu kommen und einfach die gemeinsame Zeit zu genießen. Meinem Bruder, Andreas Förster, und seiner Familie Ingrid, Georg und Clemens: Danke für euer Interesse an meiner Arbeit. Eure Unterstützungen während meines Ph.D's in Schweden haben mir immer neue Kraft gegeben. xiv "If we knew what it was, we were doing, it would not be called research, would it?" -Albert Einstein