The data sources which may help strengthen the epidemiological evidence for the hormonal hypothesis of sex determination in man

W. H. James
2001 Human Reproduction  
The hypothesis that parental hormone levels around the time of conception partially control offspring sex ratiosthough here taken to be true in substance-will need a great deal of work to specify with any accuracy. We do not know with any certainty which hormones are involved, nor how they are implicated. Answers to these two questions are only likely to emerge after prolonged experimental work. And it is fair to say that that work has not yet started. I assume that experimental workers will
more » ... tal workers will not embark on such a project until it is perfectly clear that there is a watertight case that mammalian parental hormone levels somehow influence offspring sex ratios. The present note indicates where further (human) evidence for that case will be found. In regard to human beings, much of the required information is held by clinics and registries not primarily concerned with reproductive biology. This point is illustrated here in regard to toxicology, teratology, radiation medicine, neurology, psychiatry, oncology, dermatology, rheumatology, occupational medicine and sports medicine as well as obstetrics and gynaecology. Tests (based on the hypothesis) are offered for intrauterine endocrine causes of malformations, and for pre-and post-natal endocrine causes of disease.
doi:10.1093/humrep/16.6.1081 pmid:11387272 fatcat:k5qgh7bgavdslfsrmpnbhdtgcq