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Uemura et al., have done a service to the field by providing a detailed and comprehensive review of the role of VEGF receptor 1 (VEGFR1) in retinal angiogenesis and microinflammation. The role of VEGFR1 is often simplified to that of a decoy receptor that sequesters VEGF-A and prevents it from activating its signaling receptor, VEGFR2. While this is certainly an important aspect of the function of VEGFR1 within the VEGF system, it is only a very small part of a much larger story. Complexity!doi:10.32388/kpubnk fatcat:imhyd2zorrcsvoa35muyws5d6e