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Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Colonic Nociception in Mice
2006
Biological and Pharmaceutical Bulletin
Many natural terpenoid compounds from plants exhibit antinociceptive property but very few studies have addressed their efficacy in visceral models of nociception. The present study evaluated the antinociceptive potential of oleanolic acid, a pentacyclic triterpene in the mouse model of colonic nociception induced by mustard oil. We further examined the possible participation of opioid, a a 2 -adrenergic, and transient receptor potential vanilloid 1 (TRPV1)-receptors in its mechanism. Mice were
doi:10.1248/bpb.29.82
pmid:16394515
fatcat:5vxg5y4alveudav2tiy4unvvke