Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12

Jiro Takito, Masaki Ota, Chisato Oba, Hironori Fujiwara, Kiyoshi Murata, Kikuji Yamaguchi, Nobuyuki Uozumi, Masanori Nakamura, Hiroshi Inomata, Yasushi Ohizumi
2017 Planta Medica International Open  
Prevention and treatment of Alzheimer's disease are urgent problems for elderly people in developed countries. To seek useful compounds that treat, delay the onset, or prevent the development of Alzheimer's disease, we screened natural resources using the cyclic AMP response element-dependent transcription in the PC12 cell line. We previously found that honey bee royal jelly stimulates the cyclic AMP response element-dependent transcription activity in PC12 cells. Here, we report that
more » ... , a monoterpene, enhanced the royal jelly-induced cyclic AMP response element-dependent transcription activity, whereas R-limonene showed no effect in absence of royal jelly. The enhancement was inhibited by ZM241385, an antagonist for adenosine A 2 A receptor. R-limonene also enhanced the cyclic AMP response element-dependent transcription activity activated by adenosine and AMP. Thus, R-limonene represents a novel type of modulator that enhances the CRE-dependent transcription via adenosine A 2 A receptor pathway.
doi:10.1055/s-0042-118778 fatcat:os34mi46q5a4df6p4p3ij4ftaq