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Cinnamic Acid Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Hepatic Lipogenesis and Promoting Fatty Acid Oxidation
Background: Cinnamic acid (CA)'s effect on nonalcoholic fatty liver disease (NAFLD) has not been investigated in detail. Thus, we performed this study in order to explore CA's effect on hepatic lipid metabolism and the underlying mechanisms. Method: Oleic acid (OA) was used to induce lipid accumulation in HepG2 cells. After coincubation with CA, the cells were stained with oil red O and the triglyceride (TG) content was assessed. Key genes in lipogenesis and fatty acid oxidation pathways weredoi:10.21203/rs.3.rs-578880/v1 fatcat:egsn4dkxo5f7nhcp5c4bllcagm