Objective-To evaluate the cross-sectional relationship between migraine and pre-gravid obesity; and to assess the risk of adult weight gain among women with history of a pediatric diagnosis of migraine. Background-Obesity, comorbid with pain disorders including migraine, shares common pathophysiological characteristics including systemic inflammation, and derangements in adiposetissue derived cytokines. Despite biochemical and epidemiological commonalities, obesitymigraine associations have

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... inconsistently observed. Methods-A cohort of 3,733 women was interviewed during early pregnancy. We ascertained participants' self-reported history of physician-diagnosed migraine and collected self-reported information about pre-gravid weight, adult height and net weight change from age 18 to the 3monthsperiodpriorto pregnancy. Using pre-gravid body mass index, we categorized participants as follows: lean (<18.5 kg/m 2 ); normal (18.5-24.9 kg/m 2 ); overweight (25-29.9 kg/m 2 ), obese (30-34.9 kg/m 2 ), severely obese (35-39.9 kg/m 2 ), and morbidly obese (≥ 40 kg/m 2 ). Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results-After adjusting for confounders, relative to normal weight women, obese women had a 1.48-fold increased odds of migraine(OR=1.48; 95%CI 1.12-1.96). Severely obese (OR=2.07; 95%CI 1.27-3.39) and morbidly obese (OR=2.75; 95%CI 1.60-4.70) had the highest odds of migraines. Women with a history of diagnosed pediatric migraine had a 1.67-fold higher odds of gaining ≥10.0 kg above their weight at age 18, as compared with non-migraineurs (OR=1.67; 95%CI 1.13-2.47).