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In a previous article, we considered key issues for comparing rates of excess mortality between countries and regions, with an application to European countries. This article compares the U.S. with Europe, and U.S. regions with the main European countries. The U.S. policy-makers had multiple advantages over European countries, such as Italy and Spain, in responding to the first wave of the Covid-19 pandemic: more time to react, with excess deaths lagging three weeks behind, and a younger, lessdoi:10.31219/osf.io/476mq fatcat:atfm4csgifek5memxay4fjbuym