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Live Cell Imaging: Tips and Tools
2009
Biophysical Journal
Alzheimer's disease (AD) is linked to the self-association of amyloid-b peptide (Ab), a protein of 39-43 amino acids that is normally soluble in the plasma and cerebrospinal fluid. Although large, fibrillar aggregates were long thought to be the pathogenic agents, recent evidence indicates that soluble Ab oligomers are more closely linked to disease progression. In fact, negative effects have been observed from oligomers as small as dimers and trimers. A number of compounds have been found to
doi:10.1016/j.bpj.2008.12.047
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