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Regarding the Article by Timmers et al
2009
Circulation Research
Timmers et al 1 describe exaggerated left ventricular remodeling in p50 knockout (KO) mice. The results are in sharp contrast to all reports evaluating cardiac disease models in the p50 KO to date: tumor necrosis factor-overexpressing mice, but not p50 KO mice crossed with tumor necrosis factor-overexpressing mice, did develop heart failure. 2 p50 KO mice did not develop cardiac hypertrophy after angiotensin stimulation. 3 p50 KO mice were protected from ischemia/reperfusion injury. 4 Regarding
doi:10.1161/circresaha.109.197459
pmid:19498206
fatcat:oirzh26hvzhmtnqwzvs7fx75d4