Genetic Predisposition to Myeloproliferative Neoplasms: Another Piece of the Puzzle

Maya Koren-Michowitz
2018 Acta Haematologica  
The myeloproliferative neoplasms (MPN) are clonal hematopoietic disorders characterized by the overproduction of mature myeloid cells and a prolonged disease course. The WHO classification has recently characterized 7 different MPN entities, the more common ones being BCR-ABL1-positive chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, and primary myelofibrosis [1]. Three major phenotypic drivers underlie most cases of BCR-ABL-negative MPN, including somatic mutations in
more » ... 2, most commonly the JAK2V617F mutation, CALR, and MPL. MPN occur sporadically in most cases. However, familial clustering of BCR-ABL-negative MPN has been reported, with a 5-to 7-fold increased MPN risk among first-degree relatives of MPN patients [2] . Research into the mechanisms underlying predisposition to MPN have discovered candidate genetic variants, which segregate into 1 of the following categories: rare genetic variants, found in a small number of families with a high penetrance for disease, or common variants that are prevalent in the population and result in a small increased risk to develop MPN. Two models through which germline variation may increase MPN incidence were suggested [3]: DNA hypermutability, in which certain genetic variants/ haplotypes are genetically unstable and predispose to an increased somatic mutation rate, and permissive genetic background, where acquired mutations could have survival advantage in a certain milieu. In the last issue of Acta Haematologica, Andersen et al. [4] reported on the prevalence of MPN in twin pairs from the Danish Twin Registry. In 140 identified twin pairs with a diagnosis of MPN and known zygosity status, 3 monozygotic twin pairs had a concordant MPN diagnosis, i.e., MPN was diagnosed in both twins, and all dizygotic twin pairs had a discordant MPN diagnosis. This translated into a significant difference in the concordance rate for monozygotic compared to dizygotic twins of 15% (95% CI, 0.059; 0.31) and 0% (95% CI, 0; 0.035), respectively (p = 0.016). The mean age at the time of diagnosis was 64.5 years for the discordant twins and 75.4 years for the concordant twins, similar to the age at diagnosis in the general population, in which the incidence of MPN in-
doi:10.1159/000489485 pmid:29945137 fatcat:57bl5na7cfcr7fde4i33o7vvre