The Influence of an Oxidizing Substance (Sodium Iodoxybenzoate) on the Catalase Value of the Blood and Tissues
Journal of Infectious Diseases
Sodium iodoxybenzoate is an organic peroxid. It is an iodin substitution product of orthoamido-benzoic acid containing two atoms of oxygen bound to the iodin molecule. The method of preparation of this substance and the determination of its available oxygen have been described by Loevenhart and Grovel and by Arkin." The pharmacology of this substance was first studied by Loevenhart and Grove' in the hope of obtaining some experimental evidence as to the mechanism of physiologic oxidation.
... benzoic acid and its salts seemed to be especially suited to this purpose because they can be used for intravenous injection. They found that sodium iodoxybenzoate very readily oxidizes hemoglobin to oxyhemoglobin, showing that the oxygen contained in the molecule is available for physiologic oxidation in the same manner as the oxygen taken up in the lungs. Experiments tending to show the availability of the oxygen for oxidation by the tissues were not conclusive, since sodium iodoxybenzoate was unable to furnish the oxygen necessary for the peroxid reaction. On the other hand, depression of the respiratory center and the production of long periods of apnea indicate the physiologic activity of the oxygen on the respiratory center. Following intravenous injection, there is a moderate leukocytosis which consists for the most part in an increase in the polymorphonuclear leukocytes. The bactericidal action of sodium iodoxybenzoate has been studied by Arkin," who found that it possesses a marked bactericidal action for B. typhosus, B. pyocyaneus, B. coli and Staphylococcus aureus. Moreover, its strength as a bactericide was related to its oxidizing power. In experiments with B. typhosus, sodium iodoxybenzoate proved to be 200 times as bactericidal as sodium iodbenzoate and twice as bactericidal as sodium iodosobenzoate. Sodium iodbenzoate contains no available oxygen, while' sodium iodosobenzoate contains but one molecule of available oxygen or about one-half the available oxygen of iodoxybenzoate. Sodium iodoxybenzoate in its relation to the biologic reactions has been studied by several authors. Hektoen" found that dogs which had been injected with goat blood followed by an intravenous injection of sodium iodoxybenzoate