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Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents: a performance

Ana Carolina Rozalem-Reali, Felipe Faria Pierotti, Aranda Carolina, Renata Rodrigues Cocco, Emanuel Cavalcanti Sarinho, Flavio Sano, Arnaldo Porto Neto, Nelson A Rosario, Herberto J Chong Neto, Ekaterini Simões Goudoris, Lilian Sanches Moraes, Neusa Falbo Wandalsen (+5 others)
2021 Allergologia et Immunopathologia  

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The Phadiatop Infant® (PhInf) is a panel developed to assess allergic sensitization (immunoglobulin E [IgE]) in children aged <5 years and combines inhalant and food allergens. The test has not been evaluated outside Europe. This is a cross-sectional study conducted at 11 pediatric allergy centers to evaluate PhInf as an allergic disease screening method in Brazilian children. Children as controls and patients (aged 6 months–18 years) were grouped according to their primary disease and age
more » ... . PhInf and specific serum IgE (sIgE) screening was performed for Dermatophagoides pteronyssinus (DP), cat and dog epithelia, a mix of grasses and pollens, eggs, cow's milk, peanuts, and shrimp. Values ≥ 0.35 kUA/L (or PAU/L) were considered positive. A total of 470 children and adolescents, which included 385 patients and 85 controls, participated in the study (47.7% boys, average age: 6.3 years). In all, 72.6% of the participants had positive PhInf test (n = 341), with a higher proportion of those having food allergy (92.6%), atopic dermatitis (91.9%), and those aged >13 years having allergy (95%). The PhInf and sIgE agreement between patients (Kappa = 0.94, P < 0.001) and controls (Kappa = 0.84, P < 0.001) was high. PhInf and DP agreement in patients aged >13 years was excellent (Kappa = 0.936, P < 0.001). Compared with sIgE dosage, PhInf had high sensitivity (97%) and specificity (93%). Positivity of PhInf test in this population was high and had an excellent correlation with the allergens comprising the panel. It is a useful method for screening children suspected of having allergic diseases in a non-European country.
doi:10.15586/aei.v49i5.444 fatcat:7qf66f4tznhp5bgkbm7jildwju
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Ana Carolina Rozalem-Reali, Felipe Faria Pierotti, Aranda Carolina, Renata Rodrigues Cocco, Emanuel Cavalcanti Sarinho, Flavio Sano, Arnaldo Porto Neto, Nelson A Rosario, Herberto J Chong Neto, Ekaterini Simões Goudoris, Lilian Sanches Moraes, Neusa Falbo Wandalsen, Antonio Carlos Pastorino, Jackeline Motta Franco, Maria Letícia Chavarria, Magnus Borres, Dirceu Solé. "Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents: a performance." Allergologia et Immunopathologia 49.5 (2021) 42-48