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This article examines the comorbidity concept in medical anthropology. I argue that the dearth of articles on comorbidity in medical anthropology may result from the rise of syndemic theory. Syndemics recognize how social realities shape individual illness experiences as well as distribution of diseases across populations. I discuss synergistic interactions foundational to the syndemics construct through my research of depression and diabetes comorbidity in vulnerable populations from urbandoi:10.1111/maq.12215 pmid:25865829 pmcid:PMC4600415 fatcat:c3653avw7bg3bimutp7zmh6oyi