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Improved prediction of bacterial transcription start sites
Motivation: Identifying bacterial promoters is an important step towards understanding gene regulation. In this paper, we address the problem of predicting the location of promoters and their transcription start sites (TSSs) in Escherichia coli. The accepted method for this problem is to use position weight matrices (PWMs), which define conserved motifs at the sigma-factor binding site. However this method is known to result in large numbers of false positive predictions. Results: Ourdoi:10.1093/bioinformatics/bti771 pmid:16287942 fatcat:3oczap2yfvdljagj7w2yv3gw5u