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Activation of mitochondrial TUFM ameliorates metabolic dysregulation through coordinating autophagy induction
2021
Communications Biology
AbstractDisorders of autophagy, a key regulator of cellular homeostasis, cause a number of human diseases. Due to the role of autophagy in metabolic dysregulation, there is a need to identify autophagy regulators as therapeutic targets. To address this need, we conducted an autophagy phenotype-based screen and identified the natural compound kaempferide (Kaem) as an autophagy enhancer. Kaem promoted autophagy through translocation of transcription factor EB (TFEB) without MTOR perturbation,
doi:10.1038/s42003-020-01566-0
pmid:33398033
fatcat:fftuh5fn4fgzdmcoskta5cw7na