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Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biologicaldoi:10.1016/j.colsurfb.2014.09.040 pmid:25448722 pmcid:PMC5001692 fatcat:7s4uiwwdnja6fihd6senmamqqa