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Interdependence of kallikrein-related peptidases in proteolytic networks
2010
Biological chemistry
AbstractHuman kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short pro-peptide. We searched for interconnection of KLKs within extracellular proteolytic networks leading to activation of protease zymogens and found that (i) pro-KLK activation by other KLKs is scarce, with the exception of pro-KLK11, which is efficiently activated
doi:10.1515/bc.2010.055
pmid:20302517
fatcat:vglxkiszvbe4ln6iqimfqcw6sq