Hepatitis B virus profile of patients in Karu, Karu Local Government Area of Nasarawa State, Nigeria was investigated to ascertain the level of infection. A total of three hundred and eighty-four (384) blood samples comprising of two hundred and forty (240) male and one hundred and forty-four (144) female were collected from patients using 5ml syringe and needle. The blood samples were then dispensed into ethylenediaminetetraacetic acid (EDTA) tubes. Each sample was centrifuged at 3000

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... ns per minute for 5 minutes in a centrifuge to get the plasma. Three (3) drops of each sample (plasma) was transferred into the five sample wells and results were recorded as appropriate. Results showed that male was more infected 132(68.75%) compared to their female counterparts 60(31.25%). There was a significant difference (p<0.05) with regards to rate of infection in gender. The most infected age groups were 30-39 years and 40-49 years with 72 (37.50%) and 48(25.00%) positive cases respectively. There was a significant difference (p<0.05) with respect to infection and age group. The rate of infection was high in patients who had one sexual partner 114(59.37%) followed by those without sexual partners 54(28.13%). Though there was no significant (p>0.05) difference in the rate of infection among those without and one sexual partner. Those without sexual partners were more at risk with 18(60.00%) positive HBeAg. Recovery through the HBeAb and HBcAb in patients having one sexual partner were higher with values of 132(55.00%) and 96(57.14%) respectively. Vaccination as a means of prevention is very important, therefore mass immunization of those not vaccinated should be encouraged through awareness programs.