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Objectives: The aim of present study was the formulation of donepezil hydrochloride loaded polymeric mucoadhesive microspheres for delivery via nasal route to increase the residence time and absorption of drug from the nasal mucosa. Methodologies: The microspheres were formulated by conventional spray drying technique by using gellan gum as a mucoadhesive polymer. A 3 2 full factorial design was utilized with polymer concentration (X 1 ) and liquid feed flow rate (X 2 ) as independent variablesdoi:10.5530/ijper.54.4.187 fatcat:umebcub5vfawda4dgn2d464d74