A Functional Model for Structure Learning and Parameter Estimation in Continuous Time Bayesian Network: An Application in Identifying Patterns of Multiple Chronic Conditions

Syed Hasib Akhter Faruqui, Adel Alaeddini, Jing Wang, Carlos A. Jaramillo, Mary Jo Pugh
2021 IEEE Access  
Bayesian networks are powerful statistical models to study the probabilistic relationships among sets of random variables with significant applications in disease modeling and prediction. Here, we propose a continuous time Bayesian network with conditional dependencies represented as regularized Poisson regressions to model the impact of exogenous variables on the conditional intensities of the network. We also propose an adaptive group regularization method with an intuitive early stopping
more » ... ure based on Gaussian mixture model clustering for efficient learning of the structure and parameters of the proposed network. Using a dataset of patients with multiple chronic conditions extracted from electronic health records of the Department of Veterans Affairs, we compare the performance of the proposed network with some of the existing methods in the literature for both short-term (one-year ahead) and long-term (multi-year ahead) predictions. The proposed model provides a sparse intuitive representation of the complex functional relationships between multiple chronic conditions. It also provides the capability of analyzing multiple disease trajectories over time, given any combination of preexisting conditions.
doi:10.1109/access.2021.3122912 pmid:35371895 pmcid:PMC8975131 fatcat:v4usqdpgyberjk2lsvuhtritya