Design and in-vitro evaluation of compressed Kollidon ® SR based Salbutamol Sulphate microcapsules: Effect of talc

A Moyeenul Huq, Shihab Ahmed, Qamrul Ahsan
2011 J. Chem. Pharm. Res   unpublished
Salbutamol sulphate, a bronchodilator drug for asthma, was encapsulated by (W/O) emulsion-solvent-evaporation technique using kollidon ® SR as coating polymeric material to prolong the therapeutic duration of the drug. Four different concentrations of talc were used as additives to see the changes in drug release pattern from the compressed microcapsules. Scanning electron microscopy (SEM) was performed to study the size and surface morphology of prepared microcapsules. UV-spectrophotometric
more » ... ectrophotometric method was applied to calculate the drug loading efficiency and the performance of the prepared dosage form was evaluated in terms of in-vitro dissolution studies according to USP XXX paddle method (type 2) in 400 ml distilled water (pH 7.4) for 8 hours at 37 0 ± 5 0 C temperature at 50 rpm. Release of salbutamol sulphate from the compressed microcapsules was found to follow Higuchi mechanism (R 2 =0.99). Korsmeyer equation was used to calculate the release exponent value (n) which indicates the drug release behavior and the mean dissolution time T 50% (MDT) for release rate. The surfaces of the microcapsules became smoother with the increase in talc concentration and simultaneously decrease in drug release rate.