Synthesis and Antimicrobial Properties of 1,3,4-Oxadiazole Analogs Containing Dibenzosuberane Moiety

Manjunath Moger, Vijay Satam, Darshan Raj C. Govindaraju, A. S. Paniraj, Vadiraj S. Gopinath, Rama Mohan Hindupura, Hari N. Pati
2013 Journal of the Brazilian Chemical Society  
Uma série de dez novos análogos de 1,3,4-oxadiazóis contendo uma parte dibenzosuberano foram sintetizados usando tanto uma aproximação de síntese linear, quanto convergente. Todos os compostos foram caracterizados por espectrometria de massas, espectroscopias no infravermelho (IR), de ressonância magnética nuclear de 1 H ( 1 H NMR ) e 13 C ( 13 C NMR) e análise elementar. As atividades bactericidas e antifúngicas destes compostos foram avaliadas, determinando-se que entre estes, quatro
more » ... es, quatro derivados, especificamente 8a, 8d, 8e e 8j, foram altamente bactericidas e antifúngicos. A series of ten novel 1,3,4-oxadiazole analogs containing dibenzosuberane moiety were synthesized using linear as well as convergent synthesis approach. All the compounds were characterized by mass spectrometry, infrared (IR), 1 H and 13 C nuclear magnetic resonance ( 1 H NMR and 13 C NMR) spectroscopies and elemental analysis. These compounds were evaluated for antibacterial and antifungal activities. Among ten analogs, four compounds, namely, 8a, 8d, 8e and 8j were found to be highly active antibacterial and antifungal agents.
doi:10.5935/0103-5053.20130275 fatcat:fwyjxuclonh4jgzjekg6asf72y