The doctrine of cause & effect (Karya-Karana Vada) is well versed and common in ancient Indian Philosophy Sankhya Darsana which is clinically adopted in Ayurveda. Karya-Karana Sidhanta is applicable for both Swastha and Vikara avastha. Therefore the study was conducted to evaluate the critical doctrine of Cause and Effect in the light of its clinical entity, and the efficacy of Padma (Nelumbium speciousum Willd), Priyangu (Callicarpa macrophylla Vahi) and Agnimantha (Premna intergrifolia Linn)

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... n gram negative organisms to establish the stipulated doctrine i.e. Karya-Karana Vada. This was a in-vitro study conducted on the microorganisms causing UTI commonly E. coli sp. and Klebsiella sp. The Bacteria Escherichi coli species and Klebsiella species were collected separately from the stock culture of Pathology Laboratory. Crude and Sterile Plant extract of above plant are used for the study. The crude and the sterile extract of the selected plants named Padma, Priyangu and Agnimantha are effective to inhibit the zone of colonisation of E.coli & Klebsiella in varying degree. These studies were performed in triplicate. This study concluded that micro organism enter into the bladder and kidney through urethra or any others means, they multiply in urine and change urine pH, causes Urinary Tract Infection. The responsible above said two gram negative micro-organism may or may not produce UTI, it depends upon the potentiality causative factors as justified in the doctrine of Cause and Effect (Karya-Karana Vada), and above mention three herbs shows significant anti microbial activities.