Protein kinase A-mediated septin7 phosphorylation disrupts septin filaments and ciliogenesis [post]

2020 unpublished
Septins are GTP-binding proteins that form heteromeric laments for proper cell growth and migration. Among these septins, septin7 (SEPT7) is an important component of all septin laments. Here we showed that protein kinase A (PKA) phosphorylates SEPT7 at Thr197 thus disrupting septin lament dynamics and ciliogenesis. The PKA targeting site at Thr197 of SEPT7 was conserved among species.
doi:10.21203/rs.2.23438/v1 fatcat:a7jtlvd3fjh65if6xtm3ppxdpe