A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

Karimah Kassim, Muhamad Azwan Hamali, Bohari Yamin
2019 Journal of Chemistry  
Two diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach. The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray crystallography diffraction. The analyses showed that the ligands synthesized were formed as azine instead of thiocarbohydrazone based on the missing thione, C=S moiety, throughout FTIR and NMR
more » ... scopic data. This finding was further concluded by X-ray crystal analysis. The biological properties of these ligands were screened using the disc diffusion method. The result shows that HLb shows significant inhibition towards all of the bacteria tested.
doi:10.1155/2019/9546373 fatcat:ahgbnmz6ejf3hgtrbtgbu4bdme