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THE aims of this study were to investigate the dosedependent effects of spinally delivered nociceptin (0.3, 1, 3.3 and 10 nmol) on flinching behaviour in the rat formalin test and whether these effects were influenced by the concomitant systemic administration of naloxone (3 mg/kg, i.p.). The effect of the highest nociceptin dose differed statistically from vehicle, 0.3 and 1 nmol nociceptin. Following the administration of 1, 3.3 or 10 nmol nociceptin mean total flinches decreaseddoi:10.1097/00001756-199705260-00034 pmid:9223086 fatcat:dov7opncqzcn3mww5zgvqk6yee