Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test

Katharina Erb, Jörg T. Liebel, Irmgard Tegeder, Hanns Ulrich Zeilhofer, Kay Brune, Gerd Geisslinger
1997 NeuroReport  
THE aims of this study were to investigate the dosedependent effects of spinally delivered nociceptin (0.3, 1, 3.3 and 10 nmol) on flinching behaviour in the rat formalin test and whether these effects were influenced by the concomitant systemic administration of naloxone (3 mg/kg, i.p.). The effect of the highest nociceptin dose differed statistically from vehicle, 0.3 and 1 nmol nociceptin. Following the administration of 1, 3.3 or 10 nmol nociceptin mean total flinches decreased
more » ... reased dosedependently. The effects of 10 nmol nociceptin were not reversed by a high dose of naloxone. We observed a decrease in flinching behaviour with intrathecally to the lumbar enlargement delivered nociceptin and conclude that nociceptin has antinociceptive effects in the rat formalin test.
doi:10.1097/00001756-199705260-00034 pmid:9223086 fatcat:dov7opncqzcn3mww5zgvqk6yee