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TNFα-dependent mTOR activity is required for tenotomy-induced ectopic ossification in mice
[post]
2022
unpublished
Ectopic ossifications often occur in skeletal muscles or tendons following local trauma or internal hemorrhage, and occasionally cause severe pain that limits activities of daily living. However, mechanisms underlying their development remain unknown. Here we show that dissection of the Achilles tendon promotes ectopic ossification at dissection sites in wild-type mice. We observed mTOR activation at dissection sites, and development of ectopic ossification was significantly inhibited by
doi:10.21203/rs.3.rs-1882015/v1
fatcat:q3cy7ijivrd2ngooz2havqd7dq