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Quantum Chemical Study of Molecular Recognition between Etravirine/Rilpivirine and the HIV-1 Reverse Transcriptase
2017
Madridge Journal of Novel Drug Research
Second generation non-nucleoside reverse transcriptase inhibitors (NNRTIs) etravirine and rilpivirine are essential components in the highly active antiretroviral therapy for the treatment of patients infected with human immunodeficiency virus type 1 (HIV-1). They are highly potent drugs against wild-type viruses and have exhibited excellent antiviral activities against some NNRTIs-resistant HIV-1 variants. In order to understand the underlying mechanism behind their robust resistance profile
doi:10.18689/mjndr-1000105
fatcat:jwwbw35bmjhkvk5cnyhkq55jda