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Development and Validation of LC-MS/MS Method for the Quantification of Chiral Separated R-Bicalutamide in Human Plasma
2013
American Journal of Analytical Chemistry
A simple, rapid, specific and precise liquid chromatography-tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for the quantification of chiral separated R-bicalutamide from S-bicalutamide, in human plasma. Topiramate (TPM) was used as internal standard, added to plasma sample prior to extraction using t-butyl methyl ether (TBME). Chromatographic separation was achieved on CHIRALPAK AD-RH column (150 mm × 4.6 mm, 5 μm) with acteonitrile: 0.1% formic acid Buffer (50:50
doi:10.4236/ajac.2013.42009
fatcat:ah5bdihnmnamthsdwomfq5xbrm