Glioblastoma: Equilibrium and Interconversion Between Tumor Non-Stem Cells and Tumor Stem Cells

Cristina Casalone VD
2018 Biomedical Journal of Scientific & Technical Research  
The problem of the location of glioblastoma (GB) stem cells (GSCs) and of their relationship with the microenvironment is discussed. Also in our experience, they are located in perivascular and perinecrotic niches. In the latter, as an alternative hypothesis to their origin by hypoxia through Hypoxia Inducible Factor 1, they could represent the remnants of stem cells/progenitors that populate the highly proliferative areas of GB where necrosis develops in avascular zones due to the imbalance
more » ... to the imbalance between the high proliferation rate of tumor cells and the low one of endothelial cells. On the whole, tumor stem cells and tumor non-stem cells are in equilibrium between differentiation and stemness, regulated by the microenvironment with the possibility of an interconversion of the cell statuses.
doi:10.26717/bjstr.2018.08.001680 fatcat:3wxvn7w2bzarjleu7735msoikq