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The problem of the location of glioblastoma (GB) stem cells (GSCs) and of their relationship with the microenvironment is discussed. Also in our experience, they are located in perivascular and perinecrotic niches. In the latter, as an alternative hypothesis to their origin by hypoxia through Hypoxia Inducible Factor 1, they could represent the remnants of stem cells/progenitors that populate the highly proliferative areas of GB where necrosis develops in avascular zones due to the imbalancedoi:10.26717/bjstr.2018.08.001680 fatcat:3wxvn7w2bzarjleu7735msoikq