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Differential cytokine genotype frequencies among Canadian Aboriginal and Caucasian populations
Genes and Immunity
Genetic diversity related to the human immune response is a key factor in individual and population survival throughout human history. Population diversity in disease susceptibility and resistance have been identified and linked to differences in cytokine mRNA and protein expression levels. Polymorphisms in the regulatory regions of cytokine genes can influence gene transcription levels and they have been associated with susceptibility to, and/or severity of, autoimmune disorders such asdoi:10.1038/sj.gene.6364157 pmid:15674369 fatcat:i5ehrag235elbisqsn3kv7eaza