The Standard, Intervention Measures and Health Risk for High Water Iodine Areas

Peng Liu, Lixiang Liu, Hongmei Shen, Qingzhen Jia, Jinbiao Wang, Heming Zheng, Jing Ma, Dan Zhou, Shoujun Liu, Xiaohui Su, Qinghua Sun
2014 PLoS ONE  
Our study aims to clarify the population nutrient status in locations with different levels of iodine in the water in China; to choose effective measurements of water improvement(finding other drinking water source of iodine not excess) or noniodised salt supply or combinations thereof; to classify the areas of elevated water iodine levels and the areas with endemic goiter; and to evaluate the risk factors of water iodine excess on pregnant women, lactating women and the overall population of
more » ... men. From Henan, Hebei, Shandong and Shanxi province of China, for each of 50,99 mg/L, 100,149 mg/L, 150,299 mg/L, and $300 mg/L water iodine level, three villages were selected respectively. Students of 6-12 years old and pregnant were sampled from villages of each water-iodine level of each province, excluded iodized salt consumer. Then the children's goiter volume, the children and pregnant's urinary iodine and water iodine were tested. In addition, blood samples were collected from pregnant women, lactating women and other women of reproductive age for each water iodine level in the Shanxi Province for thyroid function tests. These indicators should be matched for each person. When the water iodine exceeds 100 mg/L; the iodine nutrient of children are iodine excessive, and are adequate or more than adequate for the pregnant women. It is reasonable to define elevated water iodine areas as locations where the water iodine levels exceed 100 mg/L. The supply of non-iodised salt alone cannot ensure adequate iodine nutrition of the residents, and water improvement must be adopted, as well. Iodine excess increases the risk of certain thyroid diseases in women from one-to eightfold. Funding: The world organisations of UNICEF and GAIN funded the project. The grant numbers of UNICEF is 2011 H&N IR1 Act 17 and that of GAIN is 104641. The URL of UNICEF' website is http://www.unicef.cn, that of GAIN is http://www.gainhealth.org/. No financial relationships with any organizations that might have an interest in the submitted work in the previous three years; and no other relationships or activities that could appear to have influenced the submitted work. The UNICEF and GAIN offer valuable technique support during design and found process of the project, they also reviewed and offered valuable comments for the research report. This does not alter the authors9 adherence to all PLOS ONE policies on sharing data and materials.
doi:10.1371/journal.pone.0089608 pmid:24586909 pmcid:PMC3938487 fatcat:gtangr3i5fcrhkt4nqzi2s7ugq