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Cadherin Preserves Cohesion Across Involuting Tissues During C. elegans Neurulation
[article]
2020
bioRxiv
pre-print
The internalization of the central nervous system, termed neurulation in vertebrates, is a critical step in embryogenesis. Open questions remain as to how force propels coordinated tissue movement during the process, and little is known as to how internalization happens in invertebrates. We show that in C. elegans morphogenesis, apical constriction in the retracting pharynx drives involution of the adjacent neuroectoderm. Localized HMR-1/Cadherin mediates the inter-tissue attachment, as well as
doi:10.1101/2020.05.05.079301
fatcat:xoo4vd6eg5bobjunv2vl6zimhe