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Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro
2003
Carcinogenesis
Telomeres are critical in maintaining chromosome and genomic stability. Arsenic, a human carcinogen as well as an anticancer agent, is known for its clastogenicity. To better understand molecular mechanisms of arsenic actions, we investigated arsenite effects on telomere and telomerase and determined cell growth and apoptosis in HL-60 and HaCaT cells in vitro. Low concentrations (0.1±1 mM in HaCaT and 0.1±0.5 mM in HL-60) of arsenite increased telomerase activity, maintained or elongated
doi:10.1093/carcin/bgg141
pmid:12919960
fatcat:hafl2i75hzdx3js4nobxon35u4