INDUCTION EFFECT OF MICROALGAE SCENEDESMUS DIMORPHUS AGAINST HEMATOLOGY ON MICE (MUS MUSCULUS) SUFFERING ANEMIA DISEASES

Armaini Armaini, Marniati Salim, Panji Pribadi
2018 Asian Journal of Pharmaceutical and Clinical Research  
Objective: This study aims to investigate the potential of Scenedesmus dimorphus as a cure for aplastic anemia in mice (Mus musculus).Methods: Fifty male mice divided into five groups, mice suffering anemia due to induction of chloramphenicol. Oral administrated of S. dimorphus for 28 days with a dose of 2.5 g/50 ml, 5.0 g/50 ml, and 7.5 g/50 ml, respectively, to cure aplastic anemia in mice and samcobion as standard drug.Results: Induction of chloramphenicol caused the mice to suffering
more » ... to suffering aplastic anemia and weight loss in mice. Biomass of S. dimorphus has an effect of against hematological parameters and total blood count estimation. The result shows significant (p<0.05 ANOVA) on weight gain, an increase of erythrocyte counts, and hemoglobin level, whereas an increase of hematocrit and reticulocyte values have non-significant, and a dose of S. dimorphus 5.0 g/50 ml were the treatment most effective for anemia in mice.Conclusion: Based on the results of this study, S. dimorphus biomass has the healing benefit of aplastic anemia due to the administration of chloramphenicol.
doi:10.22159/ajpcr.2018.v11i7.24825 fatcat:u7n4e6czzjafte4v5z7vkz2l3a