Diabetic cardiomyopathy is one of the serious complication of diabetes mellitus, with a silent development and it is often underestimated, Currently available diagnostic techniques are limited in their ability to identify patients who present with uncommon symptoms or silent myocardiopathy in its early stages. Aim: To evaluate role of miRNA-378 compared to GLS as a sensitive biomarker for early detection of subclinical diabetic cardiomyopathy. Method: The echocardiographic assessment for GLS

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... done for control group (H) and normotensive diabetic patients and these patients were divided into (CD) group without cardiomyopathy, and (M)group with cardiomyopathy diagnosed by negative GLS and positive GLS, respectively .Group (F) include Hypertensive and/or ischemic diabetic patients with overt heart failure. Results: There is significant elevation in miR-378 Ct value between H in one side & other three diabetic gps. (CD, M, F) as presented in table (3-17) (p< 0.05). There is significant elevation in miR-378 Ct value in M than CD groups. There is significant elevation in Ct value in F than M gp. (p=0.000). In the ROC curve (AUC) was 0.965. The sensitivity and specificity were 0.978 and 0.646, respectively according to the chosen cut-off value. Conclusion: This study showed that miRNA-378 could be regarded as a novel sensitive biomarker which could play a significant role for early detection of subclinical diabetic cardiomyopathy.