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Journal of Virology
Cycloheximide, at a concentration of 10 ,ug/ml, rapidly blocked protein synthesis in L cells infected with reovirus. When the drug was added before 5 hr postinfection, synthesis of both single-and double-stranded varieties of virus-specific ribonucleic acid (RNA), which normally commences between 6 and 7 hr after infection, was blocked. When the cycloheximide was added at 9 hr after infection, uptake of uridine-H3 into RNA, for the succeeding 6 hr at least, was similar to that of an infecteddoi:10.1128/jvi.1.1.36-44.1967 fatcat:pkocyns5abdrrnciddrxbc3bz4